HLCS

Across TCGA cell cohorts, HLCS mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HLCS-associated genes across cancer lineages are OR2A2, DEFB124, and PIGY. Each is linked with HLCS in more than 1 cancer types. Because this analysis shows association rather than direction, both HLCS-to-partner and partner-to-HLCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2A2 grouped by HLCS-low versus HLCS-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLCS→partner) and Y-score (partner→HLCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR2A2 →	+0.046	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUSC	DEFB124 →	+0.187	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUSC	PIGY →	+1.158	+4.108	.008	.005	3	1
LUNG_SCLC	UBE2U →	+0.076	+4.684	<.001	<.001	3	1
LUNG_SCLC	HIGD1C →	+0.134	+3.898	.006	.005	3	1
LARGE_INTESTINE	C6orf118 →	+0.175	+3.793	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR2A2 by HLCS expression — URINARY_TRACT

Explore this box plot interactively →