HLA-W

Across TCGA patient cohorts, HLA-W RNA expression is significantly associated with the protein abundance of many other proteins, with 9,214 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HLA-W-associated proteins across cancer lineages are ASNS, HDGFL3, and GSPT1. Each is linked with HLA-W in more than 3 cancer types. Because this analysis shows association rather than direction, both HLA-W-to-partner and partner-to-HLA-W results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-W versus ASNS in BRCA, with a Pearson correlation of -0.27.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-W→partner) and Y-score (partner→HLA-W) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ASNS →	-0.509	-0.419	.005	.001	3	4
BRCA	HDGFL3 →	+0.581	+0.556	.007	<.001	3	4
HNSC	GSPT1 →	-0.234	-0.926	<.001	<.001	3	4
CCRCC	YME1L1 →	-0.257	-0.452	.003	.004	3	3
HNSC	NAA50 →	-0.211	-0.651	<.001	.003	3	3
BRCA	NOP2_S732 →	-1.152	-0.512	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,214 associations by consensus.

HLA-W vs ASNS — BRCA

Explore this scatter interactively →