HLA-W

Across TCGA pan-cancer cohorts, HLA-W RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HLA-W’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HLA-W RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HLA-W is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

KIRC, HNSC, and LUSC are the cancer types where HLA-W tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLA-W RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.442	<.001	11	view →
HNSC	All	II,III,IV	+0.401	<.001	10	view →
LUSC	Female	All	−0.657	<.001	8	view →
STAD	Male	II,III,IV	+0.275	.035	4	view →
CHOL	All	All	+0.502	.002	3	view →
KIRP	All	II,III,IV	+0.327	.034	2	view →
KICH	All	All	−0.281	.010	2	view →
LIHC	All	All	+0.244	.005	2	view →
BRCA	All	III,IV	−0.238	.028	2	view →
LUAD	Female	All	−0.292	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HLA-W–KIRC

Open the KIRC breakdown →