HLA-W

Across TCGA pan-cancer cohorts, HLA-W RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated HLA-W data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HLA-W RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLA-W expression acts as an unfavorable survival marker, although some lineages such as SKCM and READ show a favorable association.

SKCM, READ, and UVM are the cancer types where HLA-W RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.423	0.253	<.001	75	view →
READ	DFS	Median	All	0.787	0.346	<.001	59	view →
UVM	DFS	Quartile	All	0.386	0.786	.007	36	view →
MESO	OS	Quartile	All	0.546	0.258	.002	36	view →
ACC	OS	Median	IV	0.759	0.339	.002	36	view →
KIRC	DFS	Quartile	III,IV	0.701	0.296	.001	33	view →
STAD	OS	Tertile	III,IV	0.512	0.730	.011	25	view →
LIHC	DFS	Median	II,III,IV	0.360	0.126	.007	20	view →
CHOL	DFS	Tertile	All	0.769	0.206	.014	20	view →
LUSC	OS	Median	II,III,IV	0.285	0.677	.002	19	view →
UCS	DFS	Median	All	0.397	0.153	.020	18	view →
BLCA	DFS	Median	III,IV	0.505	0.254	.008	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

HLA-W–SKCM (OS)

Open the SKCM breakdown →