HLA-V

Across TCGA patient cohorts, HLA-V RNA expression is significantly associated with the protein abundance of many other proteins, with 10,506 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-V-associated proteins across cancer lineages are STRBP, ICAM1, and SLC16A3. Each is linked with HLA-V in more than 5 cancer types. Because this analysis shows association rather than direction, both HLA-V-to-partner and partner-to-HLA-V results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-V versus STRBP in LSCC, with a Pearson correlation of -0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-V→partner) and Y-score (partner→HLA-V) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STRBP →	-0.583	-0.541	<.001	<.001	3	6
LSCC	ICAM1 →	+0.640	+0.787	<.001	<.001	3	6
HNSC	SLC16A3 →	+0.593	+1.022	<.001	<.001	3	5
LSCC	C19orf33 →	+0.935	+0.822	<.001	<.001	3	5
PDAC	ITGA3 →	+0.547	+0.751	.003	.001	3	5
OV	LAMB3 →	+1.107	+0.772	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,506 associations by consensus.

HLA-V vs STRBP — LSCC

Explore this scatter interactively →