HLA-V

Across TCGA patient cohorts, HLA-V mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-V-associated genes across cancer lineages are Ku80, p62 Lck ligand, and STAT3_pY705. Each is linked with HLA-V in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-V-to-partner and partner-to-HLA-V results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by HLA-V-low versus HLA-V-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-V→partner) and Y-score (partner→HLA-V) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.258	+3.009	.023	.019	3	1
UCEC	p62 Lck ligand →	+0.316	+2.999	.044	.035	3	1
UCEC	STAT3_pY705 →	-0.374	-2.459	.003	.020	3	1
UCEC	VHL →	-1.004	-2.459	.002	.020	3	1
UCEC	MEK1 →	+0.507	+3.584	.004	.002	2	1
UCEC	4E-BP1_pT37_T46 →	-0.618	-3.169	<.001	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Ku80 by HLA-V expression — UCEC

Explore this box plot interactively →