HLA-K

Across TCGA patient cohorts, HLA-K mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-K-associated genes across cancer lineages are RNU6-67P, RN7SL375P, and RNA5SP124. Each is linked with HLA-K in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-K-to-partner and partner-to-HLA-K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-67P grouped by HLA-K-low versus HLA-K-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-K→partner) and Y-score (partner→HLA-K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-67P →	+0.301	+7.924	<.001	.008	3	2
SKCM	RN7SL375P →	+0.149	+5.680	<.001	.003	3	1
UCEC	RNA5SP124 →	+0.495	+3.318	.001	.002	3	1
UCEC	RNU6-23P →	+0.447	+2.967	<.001	.007	3	1
UCEC	MIR147A →	+0.197	+3.997	<.001	.009	3	1
UCEC	MIR629 →	+0.313	+3.997	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

RNU6-67P by HLA-K expression — LUSC

Explore this box plot interactively →