HLA-K

Across TCGA pan-cancer cohorts, HLA-K RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HLA-K data layer compared with 4 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HLA-K RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLA-K expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

SKCM, LIHC, and KICH are the cancer types where HLA-K RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.390	0.283	<.001	95	view →
LIHC	OS	Tertile	II,III,IV	0.349	0.711	.001	49	view →
KICH	OS	Tertile	III,IV	0.309	1.000	.004	47	view →
BLCA	DFS	Tertile	II,III,IV	0.590	0.477	.008	41	view →
UCEC	DFS	Tertile	IV	0.652	0.178	<.001	38	view →
COAD	DFS	Tertile	All	0.723	0.830	.001	36	view →
LAML	DFS	Median	All	0.311	0.606	<.001	34	view →
STAD	DFS	Tertile	All	0.272	0.504	.011	26	view →
LGG	OS	Quartile	All	0.813	0.911	<.001	22	view →
GBM	OS	Tertile	All	0.232	0.387	.001	18	view →
MESO	OS	Tertile	III,IV	0.665	0.404	.001	14	view →
PAAD	OS	Tertile	All	0.277	0.500	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HLA-K–SKCM (OS)

Open the SKCM breakdown →