Across TCGA patient cohorts, HLA-J mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-J-associated genes across cancer lineages are FoxM1, GAPDH, and PCNA. Each is linked with HLA-J in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-J-to-partner and partner-to-HLA-J results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-J→partner) and Y-score (partner→HLA-J) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.283	+3.459	.029	.005	3	1
UCEC	GAPDH →	+0.599	+2.321	.026	.035	3	1
UCEC	PCNA →	+0.269	+2.321	.013	.035	3	1
UCEC	ASNS →	+0.378	+3.169	.037	.019	3	1
UCEC	PDCD4 →	-0.759	-2.990	.001	.036	2	1
UCEC	Bid →	+0.121	+2.321	.043	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

HLA-J survival (RNA) · tumor vs normal (RNA) · all HLA-J data types