Across TCGA patient cohorts, HLA-G RNA expression is significantly associated with the go_rna of many other GO terms, with 7,109 significant associations in total. THCA shows the largest number of these associations.

The most reproducible HLA-G-associated GO terms across cancer lineages are Tolerance induction dependent upon immune response, Positive regulation of T cell tolerance induction, and Positive regulation of tolerance induction. Each is linked with HLA-G in more than 33 cancer types. Because this analysis shows association rather than direction, both HLA-G-to-partner and partner-to-HLA-G results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-G→partner) and Y-score (partner→HLA-G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Tolerance induction dependent upon immune response →	+1.600	+2.392	<.001	<.001	3	34
SCLC	Positive regulation of T cell tolerance induction →	+0.438	+2.368	<.001	<.001	3	33
SCLC	Positive regulation of tolerance induction →	+0.374	+2.297	<.001	<.001	3	32
SCLC	Negative regulation of T cell mediated immunity →	+0.126	+2.108	<.001	<.001	3	32
SCLC	Positive regulation of regulatory T cell differentiation →	+0.145	+2.082	<.001	<.001	3	31
SCLC	Antigen processing and presentation of peptide antigen via MHC class I →	+0.230	+2.224	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,109 associations by consensus.

Exploration

HLA-G survival (RNA) · tumor vs normal (RNA) · all HLA-G data types