Across TCGA pan-cancer cohorts, HLA-G RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated HLA-G data layer compared with 6 for mutation status and 1 for mass-spec protein.
The strongest signal is observed in uveal melanoma (UVM), where higher HLA-G RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HLA-G expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.
UVM, SKCM, and BLCA are the cancer types where HLA-G RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.