HLA-G

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HLA-G protein abundance is significantly associated with the RNA expression of many other genes, with 2,162 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HLA-G-associated genes across cancer lineages are GBP1, UBE2L6, and TAP1. Each is linked with HLA-G in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-G-to-partner and partner-to-HLA-G results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-G→partner) and Y-score (partner→HLA-G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVGBP1 →+1.417+1.052<.001.00132
OVUBE2L6 →+1.081+1.049.005.00132
OVTAP1 →+1.702+0.969.003.00532
OVPSMB8 →+1.230+1.099.001<.00132
OVHLA-DRA →+1.462+1.000.002.00332
OVLAP3 →+0.823+1.183<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,162 associations by consensus.

Exploration