Across TCGA patient cohorts, HLA-G mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-G-associated genes across cancer lineages are LKB1, JNK2, and Ku80. Each is linked with HLA-G in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-G-to-partner and partner-to-HLA-G results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-G→partner) and Y-score (partner→HLA-G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LKB1 →	+0.165	+2.845	.013	.033	3	2
UCEC	JNK2 →	+0.218	+3.179	.014	.010	3	1
UCEC	Ku80 →	+0.321	+3.183	.002	.009	3	1
UCEC	MEK1 →	+0.466	+3.169	.004	.018	3	1
UCEC	PDCD4 →	-0.682	-3.807	.001	<.001	3	1
UCEC	PKC-b-II_pS660 →	-0.259	-3.321	.037	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

HLA-G survival (RNA) · tumor vs normal (RNA) · all HLA-G data types