Across TCGA patient cohorts, HLA-F-AS1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-F-AS1-associated genes across cancer lineages are RNU6-340P, RNA5SP131, and H3C15. Each is linked with HLA-F-AS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-F-AS1-to-partner and partner-to-HLA-F-AS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-F-AS1→partner) and Y-score (partner→HLA-F-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-340P →	+0.630	+6.027	<.001	.002	3	1
UCEC	RNA5SP131 →	+1.274	+5.551	<.001	.004	3	1
UCEC	H3C15 →	+0.056	+5.484	<.001	.005	3	1
UCEC	RNU6-1026P →	+0.580	+5.937	<.001	.002	3	1
UCEC	RNU6-1228P →	+0.601	+7.049	<.001	<.001	3	1
UCEC	RNU6-482P →	+0.919	+5.031	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

HLA-F-AS1 survival (RNA) · tumor vs normal (RNA) · all HLA-F-AS1 data types