HLA-DRB6

Across TCGA patient cohorts, HLA-DRB6 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,962 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DRB6-associated proteins across cancer lineages are HLA-DRA, HLA-DPB1, and CD74. Each is linked with HLA-DRB6 in more than 8 cancer types. Because this analysis shows association rather than direction, both HLA-DRB6-to-partner and partner-to-HLA-DRB6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-DRB6 versus HLA-DRA in GBM, with a Pearson correlation of 0.48.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DRB6→partner) and Y-score (partner→HLA-DRB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HLA-DRA →	+0.982	+1.809	<.001	<.001	3	9
OV	HLA-DPB1 →	+0.708	+1.341	.001	.008	3	8
HNSC	CD74 →	+1.023	+1.575	<.001	<.001	3	7
HNSC	AIF1 →	+0.731	+1.559	<.001	<.001	3	7
CCRCC	HLA-DQB2 →	+1.330	+2.197	<.001	<.001	3	7
LSCC	PLCB2 →	+0.455	+1.304	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,962 associations by consensus.

HLA-DRB6 vs HLA-DRA — GBM

Explore this scatter interactively →