HLA-DRB6

Across TCGA pan-cancer cohorts, HLA-DRB6 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated HLA-DRB6 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HLA-DRB6 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLA-DRB6 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, UVM, and HNSC are the cancer types where HLA-DRB6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.412	0.280	<.001	72	view →
UVM	OS	Tertile	All	0.405	0.845	<.001	65	view →
HNSC	DFS	Median	All	0.767	0.651	.001	64	view →
LGG	OS	Median	All	0.351	0.545	<.001	54	view →
LIHC	DFS	Quartile	II,III,IV	0.619	0.347	<.001	32	view →
LAML	DFS	Tertile	All	0.344	0.612	.003	30	view →
GBM	DFS	Quartile	All	0.172	0.340	.005	24	view →
CHOL	DFS	Median	II,III,IV	0.560	0.107	.003	22	view →
UCEC	OS	Tertile	All	0.921	0.843	.007	14	view →
READ	DFS	Tertile	II,III,IV	0.839	0.686	.008	13	view →
BRCA	DFS	Median	All	0.641	0.454	.003	12	view →
CESC	OS	Quartile	All	0.860	0.705	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

HLA-DRB6–SKCM (OS)

Open the SKCM breakdown →