Across TCGA patient cohorts, HLA-DRA protein abundance is significantly associated with the RNA expression of many other genes, with 14,206 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DRA-associated genes across cancer lineages are CIITA, CD74, and HLA-DRB1. Each is linked with HLA-DRA in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-DRA-to-partner and partner-to-HLA-DRA results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DRA→partner) and Y-score (partner→HLA-DRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CIITA →	+1.259	+0.843	<.001	<.001	3	10
HNSC	CD74 →	+1.261	+0.772	<.001	<.001	3	10
UCEC	HLA-DRB1 →	+1.390	+0.588	<.001	.001	3	10
GBM	HLA-DOA →	+1.328	+1.052	<.001	<.001	3	10
HNSC	HLA-DMA →	+1.134	+0.767	<.001	<.001	3	10
COAD	PSMB8-AS1 →	+0.761	+0.727	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,206 associations by consensus.

Exploration

HLA-DRA survival (RNA) · tumor vs normal (RNA) · all HLA-DRA data types