HLA-DQB2

Across TCGA patient cohorts, HLA-DQB2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-DQB2-associated genes across cancer lineages are EGFR_pY1068, Smad3, and eEF2. Each is linked with HLA-DQB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DQB2-to-partner and partner-to-HLA-DQB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by HLA-DQB2-low versus HLA-DQB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQB2→partner) and Y-score (partner→HLA-DQB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.340	-3.321	.005	.010	3	2
UCEC	Smad3 →	+0.192	+2.999	.008	.035	3	2
UCEC	eEF2 →	+0.549	+3.584	.001	.002	3	1
UCEC	eIF4G →	+0.404	+2.459	.007	.020	3	1
UCEC	ERK2 →	+0.247	+2.459	.007	.020	3	1
UCEC	GATA6 →	-0.155	-3.452	.046	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR_pY1068 by HLA-DQB2 expression — UCEC

Explore this box plot interactively →