HLA-DQB2

Across TCGA cell cohorts, HLA-DQB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 779 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HLA-DQB2-associated GO terms across cancer lineages are Dendritic cell antigen processing and presentation, Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, and Antigen processing and presentation of endogenous antigen. Each is linked with HLA-DQB2 in more than 7 cancer types. Because this analysis shows association rather than direction, both HLA-DQB2-to-partner and partner-to-HLA-DQB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dendritic cell antigen processing and presentation grouped by HLA-DQB2-low versus HLA-DQB2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQB2→partner) and Y-score (partner→HLA-DQB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Dendritic cell antigen processing and presentation →	+1.425	+0.273	<.001	.005	3	8
BLOOD_Myeloma	Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation →	+1.310	+2.727	<.001	<.001	3	7
BLOOD_Leukemia	Antigen processing and presentation of endogenous antigen →	+0.170	+1.114	<.001	<.001	3	6
BLOOD_Myeloma	Positive regulation of dendritic cell antigen processing and presentation →	+1.515	+1.642	.003	.006	3	6
BLOOD_Myeloma	Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation →	+1.369	+2.727	<.001	<.001	3	6
PANCREAS	MHC class II protein complex assembly →	-0.278	-0.138	<.001	.008	1	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 779 associations by consensus.

Dendritic cell antigen processing and presentation by HLA-DQB2 expression — PANCREAS

Explore this box plot interactively →