HLA-DQB2

Across TCGA cell cohorts, HLA-DQB2 mutation is significantly associated with the RNA expression of many other genes, with 101 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HLA-DQB2-associated genes across cancer lineages are SPIC, LCE1B, and LCE1C. Each is linked with HLA-DQB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DQB2-to-partner and partner-to-HLA-DQB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPIC grouped by HLA-DQB2-low versus HLA-DQB2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQB2→partner) and Y-score (partner→HLA-DQB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPIC →	+0.993	+3.269	<.001	.007	3	2
BLOOD_Lymphoma	LCE1B →	+0.370	+2.222	.001	.004	3	2
BLOOD_Lymphoma	LCE1C →	+0.587	+2.328	.005	.002	3	2
BLOOD_Lymphoma	C2CD4A →	+0.027	+3.756	.004	<.001	3	2
BLOOD_Leukemia	LCE1E →	+0.625	+3.359	<.001	.002	3	2
BLOOD_Leukemia	OR2T11 →	+0.048	+3.269	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

SPIC by HLA-DQB2 expression — BLOOD_Leukemia

Explore this box plot interactively →