HLA-DQB1

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HLA-DQB1 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,672 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DQB1-associated proteins across cancer lineages are HLA-DQA1, CD74, and DOCK10. Each is linked with HLA-DQB1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-DQB1-to-partner and partner-to-HLA-DQB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-DQB1 versus HLA-DQA1 in CCRCC, with a Pearson correlation of 0.85.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQB1→partner) and Y-score (partner→HLA-DQB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCHLA-DQA1 →+1.694+1.489<.001<.001310
HNSCCD74 →+0.984+2.235<.001<.00139
UCECDOCK10 →+0.417+1.157<.001<.00139
GBMALOX5 →+0.960+1.861<.001<.00139
GBMHLA-DPB1 →+0.821+1.492<.001<.00139
LUADHLA-DRB1 →+0.642+1.295<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 17,672 associations by consensus.

HLA-DQB1 vs HLA-DQA1 — CCRCC

Per-sample scatter of HLA-DQB1 vs HLA-DQA1 in CCRCC (Pearson r = 0.85).

Explore this scatter interactively →

Exploration