HLA-DQB1

Across TCGA patient cohorts, HLA-DQB1 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-DQB1-associated genes across cancer lineages are LSM1P2, RNU6-756P, and HMGB1P50. Each is linked with HLA-DQB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DQB1-to-partner and partner-to-HLA-DQB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LSM1P2 grouped by HLA-DQB1-low versus HLA-DQB1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQB1→partner) and Y-score (partner→HLA-DQB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LSM1P2 →	+0.129	+7.640	<.001	.009	3	1
BLCA	RNU6-756P →	+0.333	+7.640	<.001	.009	3	1
SKCM	HMGB1P50 →	+0.076	+3.408	<.001	.009	3	1
BLCA	SMIM34A →	+0.049	+7.640	<.001	.009	3	1
UCEC	MIR3909 →	+0.624	+3.741	<.001	.003	3	1
LUAD	RPL7AP49 →	+0.281	+3.379	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

LSM1P2 by HLA-DQB1 expression — BLCA

Explore this box plot interactively →