HLA-DQB1

Across TCGA cell cohorts, HLA-DQB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,185 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HLA-DQB1-associated GO terms across cancer lineages are Dendritic cell antigen processing and presentation, Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, and Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation. Each is linked with HLA-DQB1 in more than 14 cancer types. Because this analysis shows association rather than direction, both HLA-DQB1-to-partner and partner-to-HLA-DQB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dendritic cell antigen processing and presentation grouped by HLA-DQB1-low versus HLA-DQB1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQB1→partner) and Y-score (partner→HLA-DQB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Dendritic cell antigen processing and presentation →	+1.692	+2.981	<.001	<.001	3	15
BLOOD_Leukemia	Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation →	+1.461	+4.078	<.001	<.001	3	14
BLOOD_Leukemia	Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation →	+1.397	+4.078	<.001	<.001	3	13
LUNG_NSCLC_LUSC	MHC class II protein complex assembly →	-0.449	-2.584	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Peptide antigen assembly with MHC class II protein complex →	-0.449	-2.584	<.001	<.001	3	11
STOMACH	Positive regulation of dendritic cell antigen processing and presentation →	+1.753	+2.501	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,185 associations by consensus.

Dendritic cell antigen processing and presentation by HLA-DQB1 expression — STOMACH

Explore this box plot interactively →