HLA-DQA2

Across TCGA patient cohorts, HLA-DQA2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-DQA2-associated genes across cancer lineages are VHL, CD49b, and C-Raf. Each is linked with HLA-DQA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DQA2-to-partner and partner-to-HLA-DQA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by HLA-DQA2-low versus HLA-DQA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQA2→partner) and Y-score (partner→HLA-DQA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.828	-3.000	.035	.037	3	1
UCEC	CD49b →	-0.347	-2.986	.034	.037	3	1
UCEC	C-Raf →	+0.257	+3.000	.001	.037	2	1
UCEC	ACVRL1 →	-0.211	-3.000	.007	.037	1	1
UCEC	TFRC →	+0.758	+3.000	.013	.037	1	1
UCEC	Tuberin →	+0.456	+3.000	.003	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

VHL by HLA-DQA2 expression — UCEC

Explore this box plot interactively →