HLA-DQA2

Across TCGA cell cohorts, HLA-DQA2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HLA-DQA2-associated genes across cancer lineages are MBD3L2, C11orf97, and IFNL4. Each is linked with HLA-DQA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DQA2-to-partner and partner-to-HLA-DQA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L2 grouped by HLA-DQA2-low versus HLA-DQA2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQA2→partner) and Y-score (partner→HLA-DQA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MBD3L2 →	+0.151	+5.228	<.001	.005	3	2
BLOOD_Lymphoma	C11orf97 →	+1.604	+5.794	<.001	<.001	3	1
BLOOD_Lymphoma	IFNL4 →	+0.021	+4.191	.001	.007	3	1
LUNG_NSCLC_LUAD	LYZL1 →	+0.027	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	GNG8 →	+0.420	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MBD3L2 by HLA-DQA2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →