Across TCGA patient cohorts, HLA-DQA1 RNA expression is significantly associated with the RNA expression of many other genes, with 14,620 significant associations in total. UVM shows the largest number of these associations.

The most reproducible HLA-DQA1-associated genes across cancer lineages are HLA-DRB5, HLA-DOA, and HLA-DMA. Each is linked with HLA-DQA1 in more than 33 cancer types. Because this analysis shows association rather than direction, both HLA-DQA1-to-partner and partner-to-HLA-DQA1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQA1→partner) and Y-score (partner→HLA-DQA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	HLA-DRB5 →	+2.949	+2.797	<.001	<.001	3	34
SKCM	HLA-DOA →	+2.940	+2.997	<.001	<.001	3	34
SKCM	HLA-DMA →	+2.248	+2.933	<.001	<.001	3	34
BLCA	HLA-DRA →	+3.167	+3.045	<.001	<.001	3	34
BLCA	HLA-DPB1 →	+2.826	+3.099	<.001	<.001	3	34
CHOL	HLA-DQB2 →	+3.660	+3.196	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,620 associations by consensus.

Exploration

HLA-DQA1 survival (RNA) · tumor vs normal (RNA) · all HLA-DQA1 data types