Across TCGA patient cohorts, HLA-DQA1 protein abundance is significantly associated with the RNA expression of many other genes, with 4,392 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HLA-DQA1-associated genes across cancer lineages are HLA-DQB1, HLA-DQB1-AS1, and HLA-DRB1. Each is linked with HLA-DQA1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-DQA1-to-partner and partner-to-HLA-DQA1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DQA1→partner) and Y-score (partner→HLA-DQA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HLA-DQB1 →	+1.895	+1.622	<.001	<.001	3	10
HNSC	HLA-DQB1-AS1 →	+1.157	+1.115	<.001	<.001	3	9
HNSC	HLA-DRB1 →	+1.656	+1.065	<.001	<.001	3	8
CCRCC	HLA-DRB5 →	+1.845	+1.737	<.001	<.001	3	6
HNSC	STAT5A →	+0.673	+1.152	<.001	<.001	3	5
LSCC	CIITA →	+0.857	+1.053	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,392 associations by consensus.

Exploration

HLA-DQA1 survival (RNA) · tumor vs normal (RNA) · all HLA-DQA1 data types