HLA-DPA1

Across TCGA patient cohorts, HLA-DPA1 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,432 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DPA1-associated proteins across cancer lineages are ARHGAP45, PLCB2, and WAS. Each is linked with HLA-DPA1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-DPA1-to-partner and partner-to-HLA-DPA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-DPA1 versus ARHGAP45 in GBM, with a Pearson correlation of 0.64.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DPA1→partner) and Y-score (partner→HLA-DPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP45 →	+0.568	+1.041	<.001	<.001	3	10
GBM	PLCB2 →	+0.572	+1.198	<.001	<.001	3	10
GBM	WAS →	+0.681	+1.280	<.001	<.001	3	10
GBM	IFI30 →	+0.824	+1.147	<.001	<.001	3	10
OV	IL16 →	+0.659	+1.463	<.001	<.001	3	10
LSCC	ANKRD44 →	+0.432	+1.165	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,432 associations by consensus.

HLA-DPA1 vs ARHGAP45 — GBM

Explore this scatter interactively →