HLA-DPA1

Across TCGA patient cohorts, HLA-DPA1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,061 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DPA1-associated genes across cancer lineages are SLC15A3, BIN2, and PYHIN1. Each is linked with HLA-DPA1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-DPA1-to-partner and partner-to-HLA-DPA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-DPA1 versus SLC15A3 in OV, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DPA1→partner) and Y-score (partner→HLA-DPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SLC15A3 →	+1.225	+0.645	<.001	.005	3	10
UCEC	BIN2 →	+1.104	+0.817	<.001	<.001	3	10
UCEC	PYHIN1 →	+0.909	+0.858	.002	<.001	3	10
UCEC	CD74 →	+1.167	+1.045	<.001	<.001	3	10
HNSC	HLA-DRB1 →	+1.398	+0.630	.001	<.001	3	10
OV	HLA-DQA1 →	+1.537	+0.708	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,061 associations by consensus.

HLA-DPA1 vs SLC15A3 — OV

Explore this scatter interactively →