HLA-DOB

Across TCGA patient cohorts, HLA-DOB RNA expression is significantly associated with the protein abundance of many other proteins, with 17,133 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DOB-associated proteins across cancer lineages are CD48, CORO1A, and GBP4. Each is linked with HLA-DOB in more than 8 cancer types. Because this analysis shows association rather than direction, both HLA-DOB-to-partner and partner-to-HLA-DOB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-DOB versus CD48 in OV, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DOB→partner) and Y-score (partner→HLA-DOB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CD48 →	+0.888	+1.041	.006	<.001	3	9
LSCC	CORO1A →	+0.590	+0.812	<.001	<.001	3	9
HNSC	GBP4 →	+0.723	+0.883	<.001	<.001	3	9
LSCC	IL16 →	+0.686	+0.868	<.001	<.001	3	9
LSCC	LCP1 →	+0.605	+0.867	<.001	<.001	3	9
OV	PSMB10 →	+0.620	+1.475	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,133 associations by consensus.

HLA-DOB vs CD48 — OV

Explore this scatter interactively →