HLA-DOB

Across TCGA pan-cancer cohorts, HLA-DOB RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HLA-DOB data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HLA-DOB RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLA-DOB expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and OV are the cancer types where HLA-DOB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.446	0.255	<.001	137	view →
HNSC	DFS	Quartile	II,III,IV	0.704	0.494	<.001	97	view →
OV	OS	Median	All	0.747	0.632	<.001	72	view →
LUAD	OS	Tertile	All	0.417	0.210	<.001	65	view →
LGG	DFS	Median	All	0.299	0.487	<.001	53	view →
UVM	DFS	Median	All	0.332	0.666	.003	45	view →
ESCA	DFS	Quartile	II,III,IV	0.611	0.219	<.001	35	view →
BRCA	DFS	Median	II,III,IV	0.631	0.436	.001	29	view →
CESC	OS	Quartile	II,III,IV	0.893	0.652	.027	26	view →
READ	OS	Median	IV	1.000	0.668	.002	24	view →
SARC	OS	Median	All	0.896	0.777	<.001	22	view →
THCA	DFS	Tertile	IV	1.000	0.478	.009	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HLA-DOB–SKCM (OS)

Open the SKCM breakdown →