HLA-DOB

Across TCGA pan-cancer cohorts, HLA-DOB RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HLA-DOB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HLA-DOB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HLA-DOB is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

KIRC, HNSC, and LUSC are the cancer types where HLA-DOB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLA-DOB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.642	<.001	11	view →
HNSC	Female	IV	+1.069	<.001	11	view →
LUSC	Female	III,IV	−1.110	<.001	7	view →
KICH	All	II,III,IV	−0.894	<.001	7	view →
THCA	All	IV	+2.550	<.001	6	view →
COAD	All	All	−0.727	<.001	6	view →
CHOL	All	All	+1.904	<.001	5	view →
LIHC	Female	All	+0.677	.004	4	view →
BRCA	All	III,IV	−0.503	.034	2	view →
ESCA	Female	All	+1.119	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HLA-DOB–KIRC

Open the KIRC breakdown →