HLA-DOB

Across TCGA patient cohorts, HLA-DOB protein abundance is significantly associated with the RNA expression of many other genes, with 10,943 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DOB-associated genes across cancer lineages are RASAL3, CD5, and ITK. Each is linked with HLA-DOB in more than 3 cancer types. Because this analysis shows association rather than direction, both HLA-DOB-to-partner and partner-to-HLA-DOB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-DOB versus RASAL3 in HNSC, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DOB→partner) and Y-score (partner→HLA-DOB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RASAL3 →	+1.641	+1.673	<.001	<.001	3	4
HNSC	CD5 →	+1.549	+2.258	<.001	.002	3	4
HNSC	ITK →	+1.813	+1.673	<.001	<.001	3	4
HNSC	PLA2G2D →	+1.890	+1.845	<.001	<.001	3	4
BRCA	CR2 →	+1.903	+2.291	.004	<.001	3	4
BRCA	CCR2 →	+1.933	+2.214	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,943 associations by consensus.

HLA-DOB vs RASAL3 — HNSC

Explore this scatter interactively →