HLA-DOB

Across TCGA patient cohorts, HLA-DOB mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-DOB-associated genes across cancer lineages are Notch1, Annexin-1, and STAT3_pY705. Each is linked with HLA-DOB in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DOB-to-partner and partner-to-HLA-DOB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by HLA-DOB-low versus HLA-DOB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DOB→partner) and Y-score (partner→HLA-DOB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.228	+3.000	.005	.037	3	1
UCEC	Annexin-1 →	+0.844	+2.827	.005	.035	3	1
UCEC	STAT3_pY705 →	-0.475	-3.000	.001	.037	3	1
UCEC	ATM →	-0.770	-3.000	.003	.037	3	1
UCEC	MEK1 →	+0.473	+3.000	.025	.037	2	1
UCEC	eIF4E →	+0.246	+3.000	.043	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by HLA-DOB expression — UCEC

Explore this box plot interactively →