HLA-DOB

Across TCGA cell cohorts, HLA-DOB RNA expression is significantly associated with the go_rna of many other GO terms, with 3,468 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HLA-DOB-associated GO terms across cancer lineages are CD8-positive, alpha-beta T cell activation, Antigen processing and presentation of exogenous peptide antigen via MHC class Ib, and MHC class II protein complex assembly. Each is linked with HLA-DOB in more than 8 cancer types. Because this analysis shows association rather than direction, both HLA-DOB-to-partner and partner-to-HLA-DOB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8-positive, alpha-beta T cell activation grouped by HLA-DOB-low versus HLA-DOB-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DOB→partner) and Y-score (partner→HLA-DOB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CD8-positive, alpha-beta T cell activation →	+0.146	+1.212	<.001	<.001	3	9
BREAST	Antigen processing and presentation of exogenous peptide antigen via MHC class Ib →	+0.273	+1.244	<.001	<.001	3	9
OESOPHAGUS	MHC class II protein complex assembly →	-0.352	-1.246	<.001	<.001	3	9
OESOPHAGUS	Peptide antigen assembly with MHC class II protein complex →	-0.352	-1.246	<.001	<.001	3	9
BREAST	Antigen processing and presentation of endogenous antigen →	+0.272	+1.163	<.001	<.001	3	8
LARGE_INTESTINE	Assembly of actomyosin apparatus involved in cytokinesis →	+0.160	+0.478	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,468 associations by consensus.

CD8-positive, alpha-beta T cell activation by HLA-DOB expression — OESOPHAGUS

Explore this box plot interactively →