HLA-DMB

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HLA-DMB RNA expression is significantly associated with the protein abundance of many other proteins, with 22,529 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DMB-associated proteins across cancer lineages are ARHGEF6, PSMB5, and PTPRC. Each is linked with HLA-DMB in more than 8 cancer types. Because this analysis shows association rather than direction, both HLA-DMB-to-partner and partner-to-HLA-DMB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-DMB versus ARHGEF6 in LSCC, with a Pearson correlation of 0.85.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DMB→partner) and Y-score (partner→HLA-DMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCARHGEF6 →+0.551+1.094<.001<.00139
HNSCPSMB5 →-0.544-1.043<.001<.00139
GBMPTPRC →+0.799+1.242<.001<.00139
LSCCRASAL3 →+0.538+1.002<.001<.00139
GBMPLCB2 →+0.663+1.252<.001<.00139
LSCCSAMSN1_S23 →+0.801+0.873<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 22,529 associations by consensus.

HLA-DMB vs ARHGEF6 — LSCC

Per-sample scatter of HLA-DMB vs ARHGEF6 in LSCC (Pearson r = 0.85).

Explore this scatter interactively →

Exploration