HLA-DMB

Across TCGA pan-cancer cohorts, HLA-DMB RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HLA-DMB data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HLA-DMB RNA is associated with better overall survival. In most high-consensus cancer types, elevated HLA-DMB expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and UCEC are the cancer types where HLA-DMB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.428	0.251	<.001	107	view →
HNSC	DFS	Median	All	0.767	0.653	<.001	72	view →
UCEC	OS	Median	All	0.919	0.825	<.001	68	view →
UVM	DFS	Median	All	0.378	0.727	.001	61	view →
LUAD	DFS	Median	All	0.728	0.600	<.001	57	view →
LGG	DFS	Median	All	0.298	0.514	<.001	54	view →
CESC	OS	Quartile	All	0.887	0.720	.007	50	view →
UCS	DFS	Tertile	IV	0.956	0.250	.024	24	view →
ACC	OS	Median	III,IV	0.572	0.899	.009	23	view →
LIHC	DFS	Tertile	III,IV	0.542	0.248	.012	20	view →
KIRC	DFS	Quartile	II,III,IV	0.837	0.502	.004	14	view →
GBM	DFS	Tertile	All	0.199	0.427	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HLA-DMB–SKCM (OS)

Open the SKCM breakdown →