HLA-DMB

Across TCGA pan-cancer cohorts, HLA-DMB RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HLA-DMB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HLA-DMB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HLA-DMB is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KIRC, KICH, and LUSC are the cancer types where HLA-DMB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HLA-DMB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.429	<.001	12	view →
KICH	Male	II,III,IV	−1.694	<.001	10	view →
LUSC	Male	II,III,IV	−2.230	<.001	8	view →
LUAD	Male	II,III,IV	−1.208	<.001	8	view →
THCA	Male	All	+0.522	.004	5	view →
STAD	All	II,III,IV	+1.181	.005	4	view →
BRCA	Female	All	+0.300	.007	4	view →
KIRP	Male	All	+0.821	.008	3	view →
LIHC	All	II,III,IV	+0.732	.017	3	view →
COAD	All	All	−0.574	.008	3	view →
PAAD	All	All	−2.120	.025	2	view →
CHOL	All	All	+1.832	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HLA-DMB–KIRC

Open the KIRC breakdown →