HLA-DMB

Across TCGA patient cohorts, HLA-DMB protein abundance is significantly associated with the RNA expression of many other genes, with 14,760 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HLA-DMB-associated genes across cancer lineages are LST1, HLA-DPA1, and CPVL. Each is linked with HLA-DMB in more than 7 cancer types. Because this analysis shows association rather than direction, both HLA-DMB-to-partner and partner-to-HLA-DMB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HLA-DMB versus LST1 in HNSC, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DMB→partner) and Y-score (partner→HLA-DMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LST1 →	+1.549	+1.114	<.001	<.001	3	8
HNSC	HLA-DPA1 →	+1.447	+0.873	<.001	<.001	3	8
HNSC	CPVL →	+1.375	+0.787	<.001	<.001	3	7
HNSC	BTK →	+1.304	+1.076	<.001	<.001	3	7
GBM	MS4A6A →	+1.350	+0.830	<.001	<.001	3	7
HNSC	SELPLG →	+1.380	+1.080	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,760 associations by consensus.

HLA-DMB vs LST1 — HNSC

Explore this scatter interactively →