HLA-DMB

Across TCGA cell cohorts, HLA-DMB RNA expression is significantly associated with the go_rna of many other GO terms, with 3,064 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HLA-DMB-associated GO terms across cancer lineages are Dendritic cell antigen processing and presentation, MHC class II protein complex assembly, and Peptide antigen assembly with MHC class II protein complex. Each is linked with HLA-DMB in more than 12 cancer types. Because this analysis shows association rather than direction, both HLA-DMB-to-partner and partner-to-HLA-DMB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dendritic cell antigen processing and presentation grouped by HLA-DMB-low versus HLA-DMB-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DMB→partner) and Y-score (partner→HLA-DMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Dendritic cell antigen processing and presentation →	+1.902	+4.421	<.001	<.001	3	13
LUNG_NSCLC_LUSC	MHC class II protein complex assembly →	-0.537	-1.181	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Peptide antigen assembly with MHC class II protein complex →	-0.537	-1.181	<.001	<.001	3	12
LUNG_NSCLC_LUSC	MHC protein complex assembly →	-0.315	-1.380	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Peptide antigen assembly with MHC protein complex →	-0.315	-1.380	<.001	<.001	3	11
LUNG_NSCLC_LUAD	Positive regulation of antigen processing and presentation →	+1.499	+2.057	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,064 associations by consensus.

Dendritic cell antigen processing and presentation by HLA-DMB expression — BLOOD_Myeloma

Explore this box plot interactively →