HJURP

Across TCGA cell cohorts, HJURP mutation is significantly associated with the mutation status of many other genes, with 3,333 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HJURP-associated genes across cancer lineages are FLT3, MYO10, and TDRD12. Each is linked with HJURP in more than 4 cancer types. Because this analysis shows association rather than direction, both HJURP-to-partner and partner-to-HJURP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FLT3 grouped by HJURP-low versus HJURP-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HJURP→partner) and Y-score (partner→HJURP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FLT3 →	+4.217	+4.217	.001	.001	1	5
BLOOD_Leukemia	MYO10 →	+2.350	+3.055	.006	.006	1	4
OVARY	TDRD12 →	+5.217	+4.562	<.001	<.001	1	4
BLOOD_Leukemia	FTMT →	+5.635	+4.479	<.001	<.001	1	4
LUNG_NSCLC_LUAD	LAMC3 →	+3.924	+5.063	.001	.001	1	4
BREAST	RREB1 →	+4.297	+4.857	.009	.009	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,333 associations by consensus.

FLT3 by HJURP expression — OVARY

Explore this box plot interactively →