HJURP

Across TCGA pan-cancer cohorts, HJURP RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of HJURP’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where HJURP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HJURP is over-expressed in tumor.

BLCA, HNSC, and LUAD are the cancer types where HJURP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HJURP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+2.998	<.001	12	view →
HNSC	Male	IV	+2.189	<.001	12	view →
LUAD	Male	III,IV	+3.501	<.001	11	view →
KIRP	Male	III,IV	+2.158	<.001	11	view →
COAD	Female	II,III,IV	+1.821	<.001	11	view →
KIRC	Male	IV	+1.517	<.001	11	view →
LUSC	Female	II,III,IV	+3.892	<.001	9	view →
STAD	Female	All	+2.742	<.001	9	view →
LIHC	Male	All	+2.077	<.001	9	view →
THCA	All	III,IV	+0.677	.001	9	view →
UCEC	All	II,III,IV	+4.115	<.001	8	view →
READ	All	All	+1.683	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

HJURP–BLCA

Open the BLCA breakdown →