HIVEP3

Across TCGA cell cohorts, HIVEP3 mutation is significantly associated with the RNA expression of many other genes, with 630 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HIVEP3-associated genes across cancer lineages are HEXIM2, BCDIN3D, and CST3. Each is linked with HIVEP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HIVEP3-to-partner and partner-to-HIVEP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HEXIM2 grouped by HIVEP3-low versus HIVEP3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIVEP3→partner) and Y-score (partner→HIVEP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HEXIM2 →	+0.630	+2.179	<.001	.001	3	3
LARGE_INTESTINE	BCDIN3D →	+0.398	+2.299	.001	<.001	3	3
LARGE_INTESTINE	CST3 →	-1.045	-2.126	<.001	<.001	3	2
LARGE_INTESTINE	CDC37L1 →	+0.462	+1.808	.001	.001	3	2
LARGE_INTESTINE	TRAPPC13 →	+0.354	+2.584	.007	.002	3	2
LARGE_INTESTINE	STXBP3 →	+0.379	+1.458	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 630 associations by consensus.

HEXIM2 by HIVEP3 expression — LARGE_INTESTINE

Explore this box plot interactively →