HIVEP3

Across TCGA pan-cancer cohorts, HIVEP3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated HIVEP3 data layer compared with 13 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher HIVEP3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HIVEP3 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

BRCA, SKCM, and LGG are the cancer types where HIVEP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.978	0.946	<.001	55	view →
SKCM	OS	Median	All	0.420	0.242	<.001	51	view →
LGG	DFS	Median	All	0.338	0.472	<.001	44	view →
LAML	DFS	Tertile	All	0.429	0.688	.002	42	view →
UVM	DFS	Quartile	II,III,IV	0.449	1.000	.004	31	view →
KIRP	DFS	Median	All	0.799	0.911	.005	29	view →
LUAD	DFS	Median	IV	0.345	0.636	.017	28	view →
SARC	OS	Quartile	All	0.260	0.734	.002	20	view →
KIRC	DFS	Quartile	IV	0.189	0.529	.001	20	view →
HNSC	DFS	Median	All	0.684	0.563	.003	19	view →
MESO	DFS	Median	III,IV	0.307	0.498	.007	16	view →
SCLC	OS	Quartile	All	0.883	0.621	.010	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

HIVEP3–BRCA (OS)

Open the BRCA breakdown →