HIVEP2

Across TCGA patient cohorts, HIVEP2 mutation is significantly associated with the RNA expression of many other genes, with 6,579 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIVEP2-associated genes across cancer lineages are PTMAP9, NCAPH, and KIF11. Each is linked with HIVEP2 in more than 5 cancer types. Because this analysis shows association rather than direction, both HIVEP2-to-partner and partner-to-HIVEP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTMAP9 grouped by HIVEP2-low versus HIVEP2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIVEP2→partner) and Y-score (partner→HIVEP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PTMAP9 →	+0.680	+3.181	<.001	<.001	3	6
LUAD	NCAPH →	+0.783	+2.502	.003	.002	3	5
LUAD	KIF11 →	+0.703	+3.477	.004	.002	3	5
LUAD	CDCA5 →	+0.775	+3.193	.005	.009	3	5
LUAD	SKA3 →	+0.654	+2.526	.005	.001	3	5
COAD	CDCA2 →	+0.803	+3.479	<.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,579 associations by consensus.

PTMAP9 by HIVEP2 expression — LUAD

Explore this box plot interactively →