HIVEP2

Across TCGA pan-cancer cohorts, HIVEP2 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated HIVEP2 data layer compared with 11 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HIVEP2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HIVEP2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, KIRC, and MESO are the cancer types where HIVEP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	II,III,IV	0.886	0.772	<.001	65	view →
KIRC	OS	Tertile	All	0.745	0.538	<.001	61	view →
MESO	OS	Tertile	II,III,IV	0.167	0.400	.005	55	view →
HNSC	DFS	Tertile	IV	0.441	0.200	.001	39	view →
THYM	DFS	Tertile	All	1.000	0.592	.006	24	view →
BLCA	DFS	Quartile	All	0.425	0.706	.002	23	view →
UCS	DFS	Tertile	IV	0.981	0.361	.024	18	view →
CHOL	DFS	Median	All	0.655	0.187	.003	18	view →
OV	OS	Quartile	III,IV	0.284	0.417	.012	18	view →
LIHC	DFS	Tertile	All	0.489	0.616	.007	14	view →
PRAD	DFS	Tertile	All	0.968	0.897	.007	14	view →
KICH	OS	Quartile	II,III,IV	0.569	1.000	.007	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

HIVEP2–SKCM (OS)

Open the SKCM breakdown →