HIP1R

Across TCGA patient cohorts, HIP1R mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIP1R-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and MEK1. Each is linked with HIP1R in more than 2 cancer types. Because this analysis shows association rather than direction, both HIP1R-to-partner and partner-to-HIP1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by HIP1R-low versus HIP1R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIP1R→partner) and Y-score (partner→HIP1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.618	+3.321	.003	.009	3	3
UCEC	14-3-3_beta →	-0.103	-1.973	.003	.029	3	2
UCEC	MEK1 →	+0.441	+2.874	<.001	<.001	3	2
UCEC	MSH2 →	-0.322	-3.781	<.001	<.001	3	2
UCEC	p27_pT157 →	-0.058	-1.861	.004	.049	3	2
UCEC	ATM →	-0.509	-2.687	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Caspase-7-cleavedD198 by HIP1R expression — UCEC

Explore this box plot interactively →