HIP1R

Across TCGA pan-cancer cohorts, HIP1R RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HIP1R’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where HIP1R RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HIP1R is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

LIHC, STAD, and COAD are the cancer types where HIP1R tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HIP1R RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	II,III,IV	+1.153	<.001	9	view →
STAD	All	All	+1.216	<.001	7	view →
COAD	All	All	+0.487	<.001	7	view →
UCEC	All	III,IV	+1.696	<.001	6	view →
BLCA	All	III,IV	+1.250	.002	6	view →
LUAD	Male	II,III,IV	+0.833	<.001	6	view →
KIRC	Male	II,III,IV	−0.586	<.001	6	view →
HNSC	All	All	+0.417	.002	6	view →
LUSC	Male	All	+0.501	<.001	5	view →
THCA	All	All	+0.306	<.001	5	view →
CHOL	Female	All	+3.710	<.001	3	view →
READ	Female	All	+1.115	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HIP1R–LIHC

Open the LIHC breakdown →