HIP1R

Across TCGA pan-cancer cohorts, HIP1R RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated HIP1R data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher HIP1R RNA is associated with better overall survival. In most high-consensus cancer types, elevated HIP1R expression acts as an unfavorable survival marker, although some lineages such as SCLC and BLCA show a favorable association.

SCLC, BLCA, and UVM are the cancer types where HIP1R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.757	0.347	<.001	101	view →
BLCA	OS	Quartile	II,III,IV	0.596	0.288	<.001	101	view →
UVM	OS	Median	All	0.953	0.745	.001	90	view →
MESO	DFS	Median	All	0.283	0.442	.003	85	view →
ACC	DFS	Median	All	0.242	0.643	<.001	72	view →
LGG	DFS	Median	All	0.818	0.655	<.001	44	view →
SKCM	OS	Tertile	III,IV	0.587	0.818	<.001	39	view →
KIRP	DFS	Median	All	0.949	0.870	.010	33	view →
LIHC	DFS	Tertile	All	0.422	0.606	<.001	29	view →
CHOL	DFS	Tertile	All	0.731	0.123	.011	20	view →
GBM	DFS	Median	All	0.248	0.157	.009	15	view →
KIRC	OS	Median	All	0.697	0.565	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

HIP1R–SCLC (OS)

Open the SCLC breakdown →