HIP1R

Across TCGA cell cohorts, HIP1R RNA expression is significantly associated with the go_rna of many other GO terms, with 5,579 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HIP1R-associated GO terms across cancer lineages are Regulation of clathrin coat assembly, Negative regulation of Arp2/3 complex-mediated actin nucleation, and Regulation of gastric acid secretion. Each is linked with HIP1R in more than 18 cancer types. Because this analysis shows association rather than direction, both HIP1R-to-partner and partner-to-HIP1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of clathrin coat assembly grouped by HIP1R-low versus HIP1R-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIP1R→partner) and Y-score (partner→HIP1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of clathrin coat assembly →	+0.238	+1.332	<.001	<.001	3	19
KIDNEY	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.248	+1.848	<.001	<.001	3	19
SKIN	Regulation of gastric acid secretion →	+1.359	+1.089	<.001	<.001	3	16
LUNG_SCLC	Negative regulation of actin nucleation →	+0.232	+1.476	<.001	<.001	3	15
SKIN	Regulation of platelet-derived growth factor receptor-beta signaling pathway →	+0.190	+1.366	<.001	<.001	3	12
STOMACH	Regulation of viral budding via host ESCRT complex →	+0.152	+1.279	.002	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,579 associations by consensus.

Regulation of clathrin coat assembly by HIP1R expression — URINARY_TRACT

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